Publications

See below for our latest and archived Publications.

Latest Publications

  • Bullfrog

    Design of a “green” one-step catalytic production of ε-caprolactam (precursor of nylon-6)

  • Polar Bear

    Synthesis of Aryl Boronic Acids via Low Temperature Metal-Halogen Exchange

  • Salamander

    Scale-up of the Reversible Addition-Fragmentation Chain Transfer (RAFT) Polymerization Using Continuous Flow Processing

  • Rattlesnake

    Advancing Commercial-Scale Continuous Crystallization

  • Zebrafish

    Title of article to go here...

  • Our Solutions

    The effect of channel geometry and wall boundary conditions on the formation of extrusion surface instabilities for LLDPE

Catalytic production of ε-caprolactam Bullfrog

Journal - Proceedings of the National Academy of Sciences, September 15, 2005, doi: 10.1073

Authors - John Meurig Thomas and Robert Raja

Design of a “green” one-step catalytic production of ε-caprolactam (precursor of nylon-6)

The ever-increasing industrial demand for nylon-6 (polycaprolactam) necessitates the development of environmentally benign methods of producing its precursor, ε-caprolactam, from cyclohexanone. It is currently manufactured in two popular double-step processes, each of which uses highly aggressive reagents, and each generates substantial quantities of largely unwanted ammonium sulfate as by-product.

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Archived Publications

Synthesis of Aryl Boronic Acids via Low Temperature Metal-Halogen Exchange Polar Bear

Journal - Org. Lett., 2010; DOI: 10.1021/ol2010006

Authors - Duncan L. Browne, Marcus Baumann, Bashir H. Harji, Ian R. Baxendale, and Steven V. Ley

Synthesis of Aryl Boronic Acids via Low Temperature Metal-Halogen Exchange

Boronic acids are versatile intermediates in synthesis that are typically used to form C-C, C-O and C-N bonds under metal catalysed conditions. Although many are commercially available, the formation of boronic acids from bespoke halogenated intermediates is often required, particularly in drug discovery programmes. Typically this is done via low temperature metal halogen exchange reactions. In a recent publication, workers from Cambridge demonstrate the use of the new 'Polar Bear' cryo-flow reactor in combination with the direct pumping of n-butyllithium solutions from the reagent bottle for extended periods of time to afford boronic acids on demand in synthetically useful quantities.

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Archived Publications

Continuous Flow Processing Salamander

Journal - Processes 2014, 2(1), 58-70; doi:10.3390/pr2010058

Authors - Nenad Micic, Alan Young, Julien Rosselgong and Christian H. Hornung

Scale-up of the Reversible Addition-Fragmentation Chain Transfer (RAFT) Polymerization Using Continuous Flow Processing

A controlled radical polymerization process using the Reversible Addition-Fragmentation Chain Transfer (RAFT) approach was scaled up by a factor of 100 from a small laboratory scale of 5 mL to a preparative scale of 500 mL, using batch and continuous flow processing. The batch polymerizations were carried out in a series of different glass vessels, using either magnetic or overhead stirring, and different modes of heating: Microwave irradiation or conductive heating in an oil bath.

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Archived Publications

Continuous Crystallization Rattlesnake

Journal - PharmTech, Oct 9, 2013

Authors - Cynthia Challener, PhD

GlaxoSmithKline, Novartis, and AstraZeneca Fund Center Focused on Advancing Commercial-Scale Continuous Crystallization

Through partnerships and collaborations between academia, industry, and the public sector, the Center for Continuous Manufacturing and Crystallization is advancing continuous crystallization technologies.

   

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Archived Publications

Placeholder Zebrafish

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Archived Publications

Channel geometry Our Solutions

J. Non-Newtonian Fluid Mech. 98 (2001) 185–199

Authors - Rulande P.G. Rutgers a,∗, Malcolm R. Mackley b

The effect of channel geometry and wall boundary conditions on the formation of extrusion surface instabilities for LLDPE

It is believed that surface instabilities can occur during the extrusion of linear low density polyethylene due to high extensional stresses at the exit of the die. Local crack development can occur at a critical stress level when melt rupture is reached. This high extensional stress results from the rearrangement of the flow at the boundary transition between the wall exit and the free surface. The stress is highest at the extrudate surface and decreases into the bulk of the material. The location of the region where the critical level is reached can determine the amplitude of the extrudate surface distortion.

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Archived Publications

Archived Publications